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Journal of Bacteriology, July 1999, p. 4125-4128, Vol. 181, No. 13
0021-9193/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.

Mutations in Catabolite Control Protein CcpA Separating Growth Effects from Catabolite Repression

Elke Küster, Tanja Hilbich, Michael K. Dahl, and Wolfgang Hillen*

Lehrstuhl für Mikrobiologie, Institut für Mikrobiologie, Biochemie und Genetik der Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Federal Republic of Germany

Received 1 February 1999/Accepted 20 April 1999

Carbon catabolite repression in Bacillus megaterium is mediated by the transcriptional regulator CcpA. A chromosomal deletion of ccpA eliminates catabolite repression and reduces the growth rate on glucose. We describe four single-amino-acid mutations in CcpA which separate the growth effect from catabolite repression, suggesting distinct regulatory pathways for these phenotypes.

* Corresponding author. Mailing address: Lehrstuhl für Mikrobiologie, Institut für Mikrobiologie, Biochemie und Genetik der Friedrich-Alexander-Universität Erlangen-Nürnberg, Staudtstr. 5, 91058 Erlangen, Federal Republic of Germany. Phone: 49-9131-8528081. Fax: 49-9131-8528082. E-mail: whillen{at}biologie.uni-erlangen.de.

Journal of Bacteriology, July 1999, p. 4125-4128, Vol. 181, No. 13
0021-9193/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.


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