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Journal of Bacteriology, July 1999, p. 4430-4434, Vol. 181, No. 14
0021-9193/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.

Biochemical and Genetic Evidence for Participation of DevR in a Phosphorelay Signal Transduction Pathway Essential for Heterocyst Maturation in Nostoc punctiforme ATCC 29133

Kari D. Hagen and John C. Meeks*

Section of Microbiology, Division of Biological Sciences, University of California, Davis, California 95616

Received 23 February 1999/Accepted 11 May 1999

In a test of the hypothesis that DevR is a response regulator protein that functions in a phosphorelay signal transduction system involved in heterocyst development in Nostoc punctiforme ATCC 29133, purified affinity-tagged DevR was shown to be phosphorylated in vitro by the noncognate sensor kinase EnvZ. Site-directed mutagenesis was used to generate N. punctiforme mutants with single amino acid substitutions at the putative phosphorylation site of DevR. These mutants exhibited a Fox- phenotype like the original devR insertion mutant UCD 311, consistent with a phosphotransferase role for DevR.

* Corresponding author. Mailing address: Section of Microbiology, Division of Biological Sciences, University of California, Davis, CA 95616. Phone: (530) 752-3346. Fax: (530) 752-9014. E-mail: jcmeeks{at}ucdavis.edu.

Journal of Bacteriology, July 1999, p. 4430-4434, Vol. 181, No. 14
0021-9193/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.


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