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Journal of Bacteriology, July 1999, p. 4435-4436, Vol. 181, No. 14
0021-9193/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.

Growth Phase-Dependent Regulation of Vsr Endonuclease May Contribute to 5-Methylcytosine Mutational Hot Spots in Escherichia coli

Georgina Macintyre, Photini Pitsikas, and Claire G. Cupples*

Biology Department, Concordia University, Montréal, Québec, Canada H36 1M8

Received 19 January 1999/Accepted 26 April 1999

Using rabbit polyclonal antibodies, we have shown that the Dcm cytosine methylase of Escherichia coli is maintained at a constant level during cell growth, while Vsr endonuclease levels are growth phase dependent. Decreased production of Vsr relative to Dcm during the log phase may contribute substantially to the mutability of 5-methylcytosine.

* Corresponding author. Mailing address: Biology Department, Concordia University, 1455 de Maisonneuve Blvd. W., Montréal, Québec, Canada H3G 1M8. Phone: (514) 848-3427. Fax: (514) 848-2881. E-mail: claire{at}vax2.concordia.ca.

Journal of Bacteriology, July 1999, p. 4435-4436, Vol. 181, No. 14
0021-9193/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.


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