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Journal of Bacteriology, August 1999, p. 4665-4668, Vol. 181, No. 15
0021-9193/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.

The Thermophilic Yeast Hansenula polymorpha Does Not Require Trehalose Synthesis for Growth at High Temperatures but Does for Normal Acquisition of Thermotolerance

Anke Reinders, Ivano Romano, Andres Wiemken, and Claudio De Virgilio*

Botanisches Institut der Universität, CH-4056 Basel, Switzerland

Received 14 April 1999/Accepted 24 May 1999

The TPS1 gene from Hansenula polymorpha, which encodes trehalose-6-phosphate (Tre6P) synthase, has been isolated and characterized. The deletion of TPS1 rendered H. polymorpha cells incapable of trehalose synthesis under conditions where wild-type cells normally accumulate high levels of trehalose. Interestingly, the loss of Tre6P synthase did not cause any obvious growth defects on a glucose-containing medium, even at high temperatures, but seriously compromised the cells' ability to acquire thermotolerance.

* Corresponding author. Mailing address: Botanisches Institut der Universität, Hebelstrasse 1, CH-4056 Basel, Switzerland. Phone: 41-61-267 2311. Fax: 41-61-267 2330. E-mail: devirgilioc{at}ubaclu.unibas.ch.

Journal of Bacteriology, August 1999, p. 4665-4668, Vol. 181, No. 15
0021-9193/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.


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