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Journal of Bacteriology, August 1999, p. 4848-4852, Vol. 181, No. 16
0021-9193/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.

Complementary and Overlapping Selectivity of the Two-Peptide Bacteriocins Plantaricin EF and JK

Gert N. Moll,1 Emile van den Akker,1 Håvard H. Hauge,2 Jon Nissen-Meyer,2 Ingolf F. Nes,3 Wil N. Konings,1 and Arnold J. M. Driessen1,*

Department of Microbiology, Groningen Biomolecular Sciences and Biotechnology Institute, University of Groningen, 9751NN Haren, The Netherlands,1 and Department of Biochemistry, University of Oslo, Oslo,2 and Department of Chemistry and Biotechnology, Agricultural University of Norway, N-1432 Ås,3 Norway

Received 19 March 1999/Accepted 7 June 1999

Plantaricin EF and JK are both two-peptide bacteriocins produced by Lactobacillus plantarum C11. The mechanism of plantaricin EF and JK action was studied on L. plantarum 965 cells. Both plantaricins form pores in the membranes of target cells and dissipate the transmembrane electrical potential (Delta psi ) and pH gradient (Delta pH). The plantaricin EF pores efficiently conduct small monovalent cations, but conductivity for anions is low or absent. Plantaricin JK pores show high conductivity for specific anions but low conductivity for cations. These data indicate that L. plantarum C11 produces bacteriocins with complementary ion selectivity, thereby ensuring efficient killing of target bacteria.

* Corresponding author. Mailing address: Department of Microbiology, University of Groningen, Kerklaan 30, 9751 NN Haren, The Netherlands. Phone: (31) (50) 3632164. Fax: (31) (50) 3632154. E-mail: A.J.M.Driessen{at}BIOL.RUG.NL.

Journal of Bacteriology, August 1999, p. 4848-4852, Vol. 181, No. 16
0021-9193/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.


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