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Journal of Bacteriology, August 1999, p. 5107-5110, Vol. 181, No. 16
0021-9193/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.

Identification of a Novel Penicillin-Binding Protein from Helicobacter pylori

Partha Krishnamurthy,1,2 Mary H. Parlow,2 John Schneider,2 Stephanie Burroughs,2 Catherine Wickland,2 Nimish B. Vakil,3 Bruce E. Dunn,1,2,* and Suhas H. Phadnis1,2

Department of Pathology, Medical College of Wisconsin,1 Pathology and Laboratory Medicine Service, Department of Veterans Affairs Medical Center,2 and Gastroenterology Diagnostic Unit, University of Wisconsin Medical School,3 Milwaukee, Wisconsin

Received 10 May 1999/Accepted 7 June 1999

The Helicobacter pylori genome encodes four penicillin-binding proteins (PBPs). PBPs 1, 2, and 3 exhibit similarities to known PBPs. The sequence of PBP 4 is unique in that it displays a novel combination of two highly conserved PBP motifs and an absence of a third motif. Expression of PBP 4, but not PBP 1, 2, or 3, is significantly increased during mid- to late-log-phase growth.

* Corresponding author. Mailing address: Clement J. Zablocki VA Medical Center, Pathology and Laboratory Medicine Service (DS-113), 5000 West National Ave., Milwaukee, WI 53295-1000. Phone: (414) 384-2000, ext. 1285. Fax: (414) 382-5319. E-mail: Bruce.Dunn{at}med.va.gov.

Journal of Bacteriology, August 1999, p. 5107-5110, Vol. 181, No. 16
0021-9193/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.


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