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Journal of Bacteriology, September 1999, p. 5512-5515, Vol. 181, No. 17
0021-9193/99/$04.00+0

Genomic Plasticity in Natural Populations of Bordetella pertussis

Scott Stibitz* and Mei-Shin Yang

Division of Bacterial Products, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, Maryland

Received 6 April 1998/Accepted 24 June 1999

We determined the genomic organization of 14 clinical strains of Bordetella pertussis isolated over an 18-month period in Alberta, Canada. The maps of these 14 strains, while demonstrating general similarity of gene order, display a number of examples of genomic rearrangements in the form of large chromosomal inversions.

* Corresponding author. Mailing address: Division of Bacterial Products, Center for Biologics Evaluation and Research, Food and Drug Administration, 8800 Rockville Pike, Bethesda, MD 20892. Phone: (301) 496-1785. Fax: (301) 402-2776. E-mail: stibitz{at}helix.nih.gov.

Journal of Bacteriology, September 1999, p. 5512-5515, Vol. 181, No. 17
0021-9193/99/$04.00+0


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