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Journal of Bacteriology, September 1999, p. 5852-5854, Vol. 181, No. 18
0021-9193/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.

A Sequence Downstream of the Initiation Codon Is Essential for Cold Shock Induction of cspB of Escherichia coli

Jean-Pierre Etchegaray and Masayori Inouye*

Department of Biochemistry, Robert Wood Johnson Medical School, University of Medicine and Dentistry of New Jersey, Piscataway, New Jersey 08854

Received 26 January 1999/Accepted 15 July 1999

Cold shock induction of cspB has been shown to be primarily regulated at the mRNA level. Here, we demonstrate that the induction of cspB at low temperature also requires the translational cis-acting element called the downstream box (DB). Full induction of cspB at low temperature is achieved in the presence of both the Shine-Dalgarno sequence and DB. We propose that the DB sequence functions as a translational enhancer for the biosynthesis of CspB to bypass the inhibitory effect in translation caused by cold shock.

* Corresponding author. Mailing address: Dept. of Biochemistry, Robert Wood Johnson Medical School, University of Medicine and Dentistry of New Jersey, Piscataway, NJ 08854. Phone: (732) 235-4115/4540. Fax: (732) 235-4559/4783. E-mail: inouye{at}rwja.umdnj.edu.

Journal of Bacteriology, September 1999, p. 5852-5854, Vol. 181, No. 18
0021-9193/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.


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