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Journal of Bacteriology, October 1999, p. 6214-6219, Vol. 181, No. 19
0021-9193/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.

Characterization of the Type 8 Capsular Gene Cluster of Streptococcus pneumoniae

Rosario Muñoz,1,2 Marta Mollerach,1,3 Rubens López,1 and Ernesto García1,*

Centro de Investigaciones Biológicas, CSIC,1 and Pharma Mar,2 Madrid, Spain, and Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires, Buenos Aires, Argentina3

Received 7 June 1999/Accepted 20 July 1999

The complete nucleotide sequence of the capsular gene cluster (cap8) responsible for the biosynthesis of the capsular polysaccharide of Streptococcus pneumoniae type 8 has been determined. The cap8 gene cluster, located between the genes dexB and aliA, is composed of 12 open reading frames. A 14.7-kb DNA fragment embracing the cap8 genes was sufficient to transform an unencapsulated type 3 S. pneumoniae strain to a strain with the type 8 capsule. A possible scenario for the evolution of pneumococcal types 2 and 8 is outlined.

* Corresponding author. Mailing address: Centro de Investigaciones Biológicas, CSIC, Velázquez 144, 28006 Madrid, Spain. Phone: (34) 81-5611800. Fax: (34) 91-5627518. E-mail: e.garcia{at}cib.csic.es.

Journal of Bacteriology, October 1999, p. 6214-6219, Vol. 181, No. 19
0021-9193/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.


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