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Journal of Bacteriology, October 1999, p. 6543-6546, Vol. 181, No. 20
0021-9193/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.

Porins in the Cell Wall of Mycobacterium tuberculosis

Bettina Kartmann,1,dagger Steffen Stengler,2 and Michael Niederweis1,*

Lehrstuhl für Mikrobiologie1 and Institut für Klinische Mikrobiologie, Immunologie und Hygiene,2 Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany

Received 17 May 1999/Accepted 11 August 1999

Lipid bilayer experiments indicated that the cell wall of Mycobacterium tuberculosis contains at least two different porins: (i) a cation-selective, heat-sensitive 0.7-nS channel which has a short-lived open state and is probably composed of 15-kDa subunits and (ii) a 3-nS, >60-kDa channel with a long-lived open state, resembling porins from fast-growing mycobacteria.

* Corresponding author. Mailing address: Lehrstuhl für Mikrobiologie, Friedrich-Alexander-Universität Erlangen-Nürnberg, Staudtstr. 5, 91058 Erlangen, Germany. Phone: 49/9131/852-8802. Fax: 49/9131/852-8082. E-mail: mnieder{at}biologie.uni-erlangen.de.

dagger Present address: MPI für Hirnforschung, Abt. Neurochemie, 60528 Frankfurt am Main, Germany.

Journal of Bacteriology, October 1999, p. 6543-6546, Vol. 181, No. 20
0021-9193/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.


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