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Journal of Bacteriology, November 1999, p. 6836-6839, Vol. 181, No. 21
0021-9193/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.

Expression of the Escherichia coli Ada Regulon in Stationary Phase: Evidence for rpoS-Dependent Negative Regulation of alkA Transcription

Paolo Landini1,2,* and Stephen J. W. Busby2

Swiss Federal Institute for Environmental Science and Technology (EAWAG), 8600 Dübendorf, Switzerland,1 and School of Biosciences, The University of Birmingham, Edgbaston, Birmingham B15 2TT, United Kingdom2

Received 28 May 1999/Accepted 30 July 1999

The Escherichia coli Ada protein activates sigma 70-dependent transcription at three different promoters (ada, aidB, and alkA) in response to alkylation damage of DNA. During stationary phase, however, the methylated form of Ada shuts off expression of alkA; this repression is specific for sigma S-dependent transcription. Thus, at the alkA promoter, the Ada protein can act as both a positive and negative modulator of the adaptive response to alkylation damage, depending on the cell's physiological state.

* Corresponding author. Mailing address: Dept. of Microbiology, EAWAG, 133 Überlandstrasse, CH-8600 Dübendorf, Switzerland. Phone: 41-1-823 5519. Fax: 41-1-823 5547. E-mail: landini{at}eawag.ch.

Journal of Bacteriology, November 1999, p. 6836-6839, Vol. 181, No. 21
0021-9193/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.


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