This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow E-mail this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Cotter, P. D.
Right arrow Articles by Hill, C.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Cotter, P. D.
Right arrow Articles by Hill, C.

 Previous Article  |  Next Article 

Journal of Bacteriology, November 1999, p. 6840-6843, Vol. 181, No. 21
0021-9193/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.

Identification and Disruption of lisRK, a Genetic Locus Encoding a Two-Component Signal Transduction System Involved in Stress Tolerance and Virulence in Listeria monocytogenes

Paul D. Cotter,1 Nathan Emerson,1 Cormac G. M. Gahan,1,2 and Colin Hill1,2,*

Department of Microbiology1 and National Food Biotechnology Centre,2 University College Cork, Cork, Ireland

Received 12 July 1999/Accepted 25 August 1999

lisRK encodes a two-component regulatory system in the food pathogen Listeria monocytogenes LO28. Following identification of the operon in an acid-tolerant Tn917 mutant, a deletion in the histidine kinase component was shown to result in a growth phase variation in acid tolerance, an ability to grow in high ethanol concentrations, and a significant reduction in virulence.

* Corresponding author. Mailing address: Department of Microbiology, University College Cork, Cork, Ireland. Phone: 353-21-902397. Fax: 353-21-903101. E-mail: c.hill{at}ucc.ie.

Journal of Bacteriology, November 1999, p. 6840-6843, Vol. 181, No. 21
0021-9193/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.


This article has been cited by other articles:

  • Senadheera, D., Krastel, K., Mair, R., Persadmehr, A., Abranches, J., Burne, R. A., Cvitkovitch, D. G. (2009). Inactivation of VicK Affects Acid Production and Acid Survival of Streptococcus mutans. J. Bacteriol. 191: 6415-6424 [Abstract] [Full Text]  
  • Gottschalk, S., Bygebjerg-Hove, I., Bonde, M., Nielsen, P. K., Nguyen, T. H., Gravesen, A., Kallipolitis, B. H. (2008). The Two-Component System CesRK Controls the Transcriptional Induction of Cell Envelope-Related Genes in Listeria monocytogenes in Response to Cell Wall-Acting Antibiotics. J. Bacteriol. 190: 4772-4776 [Abstract] [Full Text]  
  • Dunning, D. W., McCall, L. W., Powell, W. F., Arscott, W. T., McConocha, E. M., McClurg, C. J., Goodman, S. D., Spatafora, G. A. (2008). SloR modulation of the Streptococcus mutans acid tolerance response involves the GcrR response regulator as an essential intermediary. Microbiology 154: 1132-1143 [Abstract] [Full Text]  
  • Biswas, I., Drake, L., Erkina, D., Biswas, S. (2008). Involvement of Sensor Kinases in the Stress Tolerance Response of Streptococcus mutans. J. Bacteriol. 190: 68-77 [Abstract] [Full Text]  
  • Guinane, C. M., Cotter, P. D., Lawton, E. M., Hill, C., Ross, R. P. (2007). Insertional Mutagenesis To Generate Lantibiotic Resistance in Lactococcus lactis. Appl. Environ. Microbiol. 73: 4677-4680 [Abstract] [Full Text]  
  • Papadimitriou, K., Pratsinis, H., Nebe-von-Caron, G., Kletsas, D., Tsakalidou, E. (2007). Acid Tolerance of Streptococcus macedonicus as Assessed by Flow Cytometry and Single-Cell Sorting. Appl. Environ. Microbiol. 73: 465-476 [Abstract] [Full Text]  
  • de Been, M., Francke, C., Moezelaar, R., Abee, T., Siezen, R. J. (2006). Comparative analysis of two-component signal transduction systems of Bacillus cereus, Bacillus thuringiensis and Bacillus anthracis.. Microbiology 152: 3035-3048 [Abstract] [Full Text]  
  • Liu, S., Bayles, D. O., Mason, T. M., Wilkinson, B. J. (2006). A Cold-Sensitive Listeria monocytogenes Mutant Has a Transposon Insertion in a Gene Encoding a Putative Membrane Protein and Shows Altered (p)ppGpp Levels.. Appl. Environ. Microbiol. 72: 3955-3959 [Abstract] [Full Text]  
  • Gray, M. J., Freitag, N. E., Boor, K. J. (2006). How the Bacterial Pathogen Listeria monocytogenes Mediates the Switch from Environmental Dr. Jekyll to Pathogenic Mr. Hyde. Infect. Immun. 74: 2505-2512 [Full Text]  
  • Bonnet, M., Rafi, M. M., Chikindas, M. L., Montville, T. J. (2006). Bioenergetic Mechanism for Nisin Resistance, Induced by the Acid Tolerance Response of Listeria monocytogenes. Appl. Environ. Microbiol. 72: 2556-2563 [Abstract] [Full Text]  
  • Sachs, G., Weeks, D. L., Wen, Y., Marcus, E. A., Scott, D. R., Melchers, K. (2005). Acid Acclimation by Helicobacter pylori. Physiology 20: 429-438 [Abstract] [Full Text]  
  • Rea, R., Hill, C., Gahan, C. G. M. (2005). Listeria monocytogenes PerR Mutants Display a Small-Colony Phenotype, Increased Sensitivity to Hydrogen Peroxide, and Significantly Reduced Murine Virulence. Appl. Environ. Microbiol. 71: 8314-8322 [Abstract] [Full Text]  
  • Zhang, C., Nietfeldt, J., Zhang, M., Benson, A. K. (2005). Functional Consequences of Genome Evolution in Listeria monocytogenes: the lmo0423 and lmo0422 Genes Encode {sigma}C and LstR, a Lineage II-Specific Heat Shock System. J. Bacteriol. 187: 7243-7253 [Abstract] [Full Text]  
  • Azcarate-Peril, M. A., McAuliffe, O., Altermann, E., Lick, S., Russell, W. M., Klaenhammer, T. R. (2005). Microarray Analysis of a Two-Component Regulatory System Involved in Acid Resistance and Proteolytic Activity in Lactobacillus acidophilus. Appl. Environ. Microbiol. 71: 5794-5804 [Abstract] [Full Text]  
  • Chen, Y., Zhang, W., Knabel, S. J. (2005). Multi-Virulence-Locus Sequence Typing Clarifies Epidemiology of Recent Listeriosis Outbreaks in the United States. J. Clin. Microbiol. 43: 5291-5294 [Abstract] [Full Text]  
  • Stack, H. M., Sleator, R. D., Bowers, M., Hill, C., Gahan, C. G. M. (2005). Role for HtrA in Stress Induction and Virulence Potential in Listeria monocytogenes. Appl. Environ. Microbiol. 71: 4241-4247 [Abstract] [Full Text]  
  • Cotter, P. D., Ryan, S., Gahan, C. G. M., Hill, C. (2005). Presence of GadD1 Glutamate Decarboxylase in Selected Listeria monocytogenes Strains Is Associated with an Ability To Grow at Low pH. Appl. Environ. Microbiol. 71: 2832-2839 [Abstract] [Full Text]  
  • Williams, T., Bauer, S., Beier, D., Kuhn, M. (2005). Construction and Characterization of Listeria monocytogenes Mutants with In-Frame Deletions in the Response Regulator Genes Identified in the Genome Sequence. Infect. Immun. 73: 3152-3159 [Abstract] [Full Text]  
  • Altermann, E., Russell, W. M., Azcarate-Peril, M. A., Barrangou, R., Buck, B. L., McAuliffe, O., Souther, N., Dobson, A., Duong, T., Callanan, M., Lick, S., Hamrick, A., Cano, R., Klaenhammer, T. R. (2005). Inaugural Article: From the Cover: Complete genome sequence of the probiotic lactic acid bacterium Lactobacillus acidophilus NCFM. Proc. Natl. Acad. Sci. USA 102: 3906-3912 [Abstract] [Full Text]  
  • Zhang, W., Jayarao, B. M., Knabel, S. J. (2004). Multi-Virulence-Locus Sequence Typing of Listeria monocytogenes. Appl. Environ. Microbiol. 70: 913-920 [Abstract] [Full Text]  
  • Rea, R. B., Gahan, C. G. M., Hill, C. (2004). Disruption of Putative Regulatory Loci in Listeria monocytogenes Demonstrates a Significant Role for Fur and PerR in Virulence. Infect. Immun. 72: 717-727 [Abstract] [Full Text]  
  • Kallipolitis, B. H., Ingmer, H., Gahan, C. G., Hill, C., Sogaard-Andersen, L. (2003). CesRK, a Two-Component Signal Transduction System in Listeria monocytogenes, Responds to the Presence of Cell Wall-Acting Antibiotics and Affects {beta}-Lactam Resistance. Antimicrob. Agents Chemother. 47: 3421-3429 [Abstract] [Full Text]  
  • Cotter, P. D., Hill, C. (2003). Surviving the Acid Test: Responses of Gram-Positive Bacteria to Low pH. Microbiol. Mol. Biol. Rev. 67: 429-453 [Abstract] [Full Text]  
  • Autret, N., Raynaud, C., Dubail, I., Berche, P., Charbit, A. (2003). Identification of the agr Locus of Listeria monocytogenes: Role in Bacterial Virulence. Infect. Immun. 71: 4463-4471 [Abstract] [Full Text]  
  • Greenacre, E. J., Brocklehurst, T. F., Waspe, C. R., Wilson, D. R., Wilson, P. D. G. (2003). Salmonella enterica Serovar Typhimurium and Listeria monocytogenes Acid Tolerance Response Induced by Organic Acids at 20{degrees}C: Optimization and Modeling. Appl. Environ. Microbiol. 69: 3945-3951 [Abstract] [Full Text]  
  • Begley, M., Gahan, C. G. M., Hill, C. (2002). Bile Stress Response in Listeria monocytogenes LO28: Adaptation, Cross-Protection, and Identification of Genetic Loci Involved in Bile Resistance. Appl. Environ. Microbiol. 68: 6005-6012 [Abstract] [Full Text]  
  • Li, Y.-H., Lau, P. C. Y., Tang, N., Svensater, G., Ellen, R. P., Cvitkovitch, D. G. (2002). Novel Two-Component Regulatory System Involved in Biofilm Formation and Acid Resistance in Streptococcus mutans. J. Bacteriol. 184: 6333-6342 [Abstract] [Full Text]  
  • Hancock, L., Perego, M. (2002). Two-Component Signal Transduction in Enterococcus faecalis. J. Bacteriol. 184: 5819-5825 [Full Text]  
  • Cotter, P. D., Guinane, C. M., Hill, C. (2002). The LisRK Signal Transduction System Determines the Sensitivity of Listeria monocytogenes to Nisin and Cephalosporins. Antimicrob. Agents Chemother. 46: 2784-2790 [Abstract] [Full Text]  
  • Conte, M. P., Petrone, G., Di Biase, A. M., Longhi, C., Penta, M., Tinari, A., Superti, F., Fabozzi, G., Visca, P., Seganti, L. (2002). Effect of Acid Adaptation on the Fate of Listeria monocytogenes in THP-1 Human Macrophages Activated by Gamma Interferon. Infect. Immun. 70: 4369-4378 [Abstract] [Full Text]  
  • Czuprynski, C. J., Faith, N. G., Steinberg, H. (2002). Ability of the Listeria monocytogenes Strain Scott A To Cause Systemic Infection in Mice Infected by the Intragastric Route. Appl. Environ. Microbiol. 68: 2893-2900 [Abstract] [Full Text]  
  • Teng, F., Wang, L., Singh, K. V., Murray, B. E., Weinstock, G. M. (2002). Involvement of PhoP-PhoS Homologs in Enterococcus faecalis Virulence. Infect. Immun. 70: 1991-1996 [Abstract] [Full Text]  
  • Vazquez-Boland, J. A., Kuhn, M., Berche, P., Chakraborty, T., Dominguez-Bernal, G., Goebel, W., Gonzalez-Zorn, B., Wehland, J., Kreft, J. (2001). Listeria Pathogenesis and Molecular Virulence Determinants. Clin. Microbiol. Rev. 14: 584-640 [Abstract] [Full Text]  
  • Gahan, C. G. M., O'Mahony, J., Hill, C. (2001). Characterization of the groESL Operon in Listeria monocytogenes: Utilization of Two Reporter Systems (gfp and hly) for Evaluating In Vivo Expression. Infect. Immun. 69: 3924-3932 [Abstract] [Full Text]  


Copyright © 2010 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»