Identification and Disruption of lisRK, a Genetic Locus Encoding a Two-Component Signal Transduction System Involved in Stress Tolerance and Virulence in Listeria monocytogenes

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Journal of Bacteriology, November 1999, p. 6840-6843, Vol. 181, No. 21
0021-9193/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.

Identification and Disruption of lisRK, a Genetic Locus Encoding a Two-Component Signal Transduction System Involved in Stress Tolerance and Virulence in Listeria monocytogenes

Paul D. Cotter,¹ Nathan Emerson,¹ Cormac G. M. Gahan,¹^,² and Colin Hill¹^,²^,^*

Department of Microbiology¹ and National Food Biotechnology Centre,² University College Cork, Cork, Ireland

Received 12 July 1999/Accepted 25 August 1999

lisRK encodes a two-component regulatory system in the food pathogen Listeria monocytogenes LO28. Following identificationof the operon in an acid-tolerant Tn917 mutant, a deletion inthe histidine kinase component was shown to result in a growthphase variation in acid tolerance, an ability to grow in highethanol concentrations, and a significant reduction invirulence.

^* Corresponding author. Mailing address: Department of Microbiology, University College Cork, Cork, Ireland. Phone: 353-21-902397.Fax: 353-21-903101. E-mail: c.hill{at}ucc.ie.

Journal of Bacteriology, November 1999, p. 6840-6843, Vol. 181, No. 21
0021-9193/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.

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