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Journal of Bacteriology, December 1999, p. 7381-7384, Vol. 181, No. 23
0021-9193/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.

Negative Regulation of the Gene for Fe-Containing Superoxide Dismutase by an Ni-Responsive Factor in Streptomyces coelicolor

Hye-Jung Chung,dagger Jae-Hyun Choi, Eun-Ja Kim,Dagger You-Hee Cho, and Jung-Hye Roe*

Department of Microbiology, College of Natural Sciences, and Research Center for Molecular Microbiology, Seoul National University, Seoul 151-742, Korea

Received 19 May 1999/Accepted 13 September 1999

In Streptomyces coelicolor, transcription of the sodF genes, encoding Fe-containing superoxide dismutases, is negatively regulated by nickel. Gel mobility shift assays with sodF1 promoter fragments and cell extracts from the A3(2) strain indicate the presence of a nickel-responsive DNA-binding protein, most likely a transcriptional repressor. The boundary for the Ni-responsive cis-acting region was identified both in vitro and vivo. Ni does not regulate the level of the putative repressor but only the binding competence of this protein.

* Corresponding author. Mailing address: Department of Microbiology, College of Natural Sciences, Seoul National University, Seoul 151-742, Korea. Phone: 82-2-880-6706. Fax: 82-2-888-4911. E-mail: jhroe{at}plaza.snu.ac.kr.

dagger Present address: Laboratory of Pathology, DCS, NCI, National Institutes of Health, Bethesda, Md.

Dagger Present address: Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA 92037.

Journal of Bacteriology, December 1999, p. 7381-7384, Vol. 181, No. 23
0021-9193/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.


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