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Journal of Bacteriology, December 1999, p. 7618-7620, Vol. 181, No. 24
0021-9193/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.

CDC64 Encodes Cytoplasmic Alanyl-tRNA Synthetase, Ala1p, of Saccharomyces cerevisiae

Carolyn Wrobel,1 Emmett V. Schmidt,1,2,* and Michael Polymenis1,dagger

MGH Cancer Center, Massachusetts General Hospital, Charlestown, Massachusetts 02129,1 and Pediatric Service, Massachusetts General Hospital, and Department of Pediatrics, Harvard Medical School, Boston, Massachusetts 021142

Received 29 June 1999/Accepted 30 September 1999

The cdc64-1 mutation causes G1 arrest in Saccharomyces cerevisiae corresponding to a type II Start phenotype. We report that CDC64 encodes Ala1p, an alanyl-tRNA synthetase. Thus, cdc64-1 might affect charging of tRNAAla and thereby initiation of cell division.

* Corresponding author. Mailing address: Laboratory of Tumor Biology, The MGH Cancer Center, Massachusetts General Hospital-Harvard Medical School, Building 149, 13th St., Charlestown, MA 02129. Phone: (617) 726-5707. Fax: (617) 726-5637. E-mail: schmidt{at}helix.mgh.harvard.edu.

dagger Present address: Department of Biochemistry and Biophysics, Texas A&M University, College Station, TX 77843-2128.

Journal of Bacteriology, December 1999, p. 7618-7620, Vol. 181, No. 24
0021-9193/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.


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