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Journal of Bacteriology, December 1999, p. 7634-7638, Vol. 181, No. 24
0021-9193/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.

Mutations in Catabolite Control Protein CcpA Showing Glucose-Independent Regulation in Bacillus megaterium

Elke Küster-Schöck,1,dagger Andrea Wagner,1 Uwe Völker,2 and Wolfgang Hillen1,*

Lehrstuhl für Mikrobiologie, Friedrich-Alexander-Universität Erlangen-Nürnberg, 91058 Erlangen,1 and Laboratorium für Mikrobiologie, Philipps-Universität Marburg and Max-Planck-Institut für Terrestrische Mikrobiologie, Marburg,2 Federal Republic of Germany

Received 26 April 1999/Accepted 1 October 1999

We identified five single amino acid exchanges in CcpA that lead to permanent repression of the xylose utilization genes in the absence of glucose. Other proteins from the CcpA regulon also show glucose-independent regulation in the mutants. The mutant CcpA proteins bind to the DNA target catabolite responsive elements without the corepressor HPr-Ser-P.

* Corresponding author. Mailing address: Lehrstuhl für Mikrobiologie, Friedrich-Alexander-Universität Erlangen-Nürnberg, Staudtstr. 5, 91058 Erlangen, Federal Republic of Germany. Phone: 49-9131-8528081. Fax: 49-9131-8528082. E-mail: whillen{at}biologie.uni-erlangen.de.

dagger Present address: Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts.

Journal of Bacteriology, December 1999, p. 7634-7638, Vol. 181, No. 24
0021-9193/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.


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