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Journal of Bacteriology, February 1999, p. 1043-1044, Vol. 181, No. 3
0021-9193/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.

Escherichia coli Cells Exposed to Streptomycin Display a Mutator Phenotype

Li Ren, M. Sayeedur Rahman, and M. Zafri Humayun*

Department of Microbiology and Molecular Genetics, University of Medicine and Dentistry of New Jersey-New Jersey Medical School, Newark, New Jersey 07103-2714

Received 4 September 1998/Accepted 20 November 1998

Mistranslation mediated by the mutA and mutC tRNA alleles elicits a strong mutator phenotype (H. S. Murphy and M. Z. Humayun, J. Bacteriol. 179:7507-7514, 1997; M. M. Slupska, C. Baikalov, R. Lloyd, and J. H. Miller, Proc. Natl. Acad. Sci. USA 93:4380-4385, 1996). Here, we show that exposure to streptomycin, an antibiotic known to promote mistranslation, induces a recA- and umuDC-independent mutator phenotype detected as enhanced mutagenesis at a 3,N4-ethenocytosine lesion borne on transfected M13 single-stranded DNA.

* Corresponding author. Mailing address: Department of Microbiology and Molecular Genetics, University of Medicine and Dentistry of New Jersey-New Jersey Medical School, 185 S. Orange Ave., MSB-F607, Newark, NJ 07103-2714. Phone: (973) 972-5217. Fax: (973) 972-3644. E-mail: humayun{at}umdnj.edu.

Journal of Bacteriology, February 1999, p. 1043-1044, Vol. 181, No. 3
0021-9193/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.


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