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Journal of Bacteriology, February 1999, p. 1149-1155, Vol. 181, No. 4
0021-9193/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.

Spectra of Spontaneous Growth-Dependent and Adaptive Mutations at ebgR

Barry G. Hall*

University of Rochester, Rochester, New York

Received 15 July 1998/Accepted 10 December 1998

A comparison of the spectra of spontaneous growth-dependent and adaptive mutations in ebgR shows that both spectra are dominated by insertion sequence (IS)-mediated mutations. The difference between growth-dependent mutations (61% IS mediated) and adaptive mutations (80% IS mediated) is highly significant (P < 0.0001). In contrast, the spectra of growth-dependent and adaptive non-IS-mediated mutations do not differ from each other and therefore do not provide support for the hypothesis that adaptive and growth-dependent mutations arise by substantially different mechanisms.

* Mailing address: Biology Department, River Campus, University of Rochester, Rochester, NY 14627. Phone: (716) 275-0721. Fax: (716) 275-2070. E-mail: drbh{at}uhura.cc.rochester.edu.

Journal of Bacteriology, February 1999, p. 1149-1155, Vol. 181, No. 4
0021-9193/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.


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