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Journal of Bacteriology, February 1999, p. 1348-1351, Vol. 181, No. 4
0021-9193/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.

The Lethal Effect of a Benzamide Derivative, 3-Methoxybenzamide, Can Be Suppressed by Mutations within a Cell Division Gene, ftsZ, in Bacillus subtilis

Yoshiaki Ohashi,1 Yoshie Chijiiwa,1 Koichiro Suzuki,1 Kouki Takahashi,1 Hideaki Nanamiya,1 Tsutomu Sato,2 Yoshiko Hosoya,3 Kozo Ochi,3 and Fujio Kawamura1,*

Laboratory of Molecular Genetics, College of Science, Rikkyo (St. Paul's) University, Toshima-ku, Tokyo 171-8501,1 Department of Applied Biological Science, Tokyo University of Agriculture and Technology, Fuchu, Tokyo 183-0054,2 and National Food Research Institute, Tsukuba, Ibaraki 305-8642,3 Japan

Received 4 August 1998/Accepted 30 November 1998

3-Methoxybenzamide (3-MBA), which is known to be an inhibitor of ADP-ribosyltransferase, inhibits cell division in Bacillus subtilis, leading to filamentation and eventually lysis of cells. Our genetic analysis of 3-MBA-resistant mutants indicated that the primary target of the drug is the cell division system involving FtsZ function during both vegetative growth and sporulation.

* Corresponding author. Mailing address: Laboratory of Molecular Genetics, College of Science, Rikkyo (St. Paul's) University, 3-34-1 Nishi-ikebukuro, Toshima-ku, Tokyo 171-8501, Japan. Phone and fax: 81-3-3985-2401. E-mail: kawamura{at}rikkyo.ac.jp.

Journal of Bacteriology, February 1999, p. 1348-1351, Vol. 181, No. 4
0021-9193/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.


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