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 Previous Article

Journal of Bacteriology, February 1999, p. 1369-1373, Vol. 181, No. 4
0021-9193/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.

Lack of Genetic Differentiation between Two Geographically Diverse Samples of Candida albicans Isolated from Patients Infected with Human Immunodeficiency Virus

Jianping Xu,1,2,* Rytas Vilgalys,2 and Thomas G. Mitchell1

Department of Microbiology, Duke University Medical Center, Durham, North Carolina 27710,1 and Department of Botany, Duke University, Durham, North Carolina 277082

Received 22 July 1998/Accepted 30 November 1998

The patterns of genetic variation of samples of Candida albicans isolated from patients infected with human immunodeficiency virus in Durham, N.C., and Vitória, Brazil, were compared. Genotypes for 126 strains were obtained at 16 polymorphic restriction sites distributed on nine PCR fragments. The results indicated evidence of clonality both within and between these two geographically diverse samples. The samples are genetically very similar, with little evidence of genetic differentiation.

* Corresponding author. Mailing address: Department of Microbiology, Box 3020, Duke University Medical Center, Durham, NC 27710. Phone: (919) 684-9096. Fax: (919) 681-8911. E-mail: jpxu{at}acpub.duke.edu.

Journal of Bacteriology, February 1999, p. 1369-1373, Vol. 181, No. 4
0021-9193/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.


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