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Journal of Bacteriology, March 1999, p. 1944-1946, Vol. 181, No. 6
Department of Biochemistry, St Jude
Children's Research Hospital, Memphis, Tennessee
38101,1 and Department of
Biochemistry, University of Tennessee, Memphis, Tennessee
381632
Received 3 December 1998/Accepted 14 January 1999
The sn-glycerol-3-phosphate acyltransferase
(plsB) catalyzes the first step in membrane phospholipid
formation. A conditional Escherichia coli mutant
(plsB26) has a single missense mutation (G1045A) predicting
the expression of an acyltransferase with an Ala349Thr substitution.
The PlsB26 protein had a significantly reduced glycerol-3-phosphate
acyltransferase specific activity coupled with an elevated
Km for glycerol-3-phosphate.
0021-9193/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.
A Missense Mutation Accounts for the Defect in
the Glycerol-3-Phosphate Acyltransferase Expressed in the
plsB26 Mutant
*
Corresponding author. Mailing address: Department of
Biochemistry, St. Jude Children's Research Hospital, 332 N. Lauderdale, Memphis, TN 38105-2794. Phone: 901-495-3491. Fax:
901-525-8025. E-mail: charles.rock{at}stjude.org.
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