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Journal of Bacteriology, March 1999, p. 1968-1970, Vol. 181, No. 6
0021-9193/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.

Escherichia coli Outer Membrane Protein TolC Is Involved in Production of the Peptide Antibiotic Microcin J25

Mónica A. Delgado, José O. Solbiati, María J. Chiuchiolo, Ricardo N. Farías, and Raúl A. Salomón*

Departamento de Bioquímica de la Nutrición, Instituto Superior de Investigaciones Biológicas (Consejo Nacional de Investigaciones Científicas y Técnicas-Universidad Nacional de Tucumán), and Instituto de Química Biológica "Dr. Bernabé Bloj," 4000 San Miguel de Tucumán, Tucumán, Argentina

Received 16 October 1998/Accepted 4 January 1999

A Tn5 insertion in tolC eliminated microcin J25 production. The mutation had little effect on the expression of the microcin structural gene and presumably acted by blocking microcin secretion. The tolC mutants carrying multiple copies of the microcin genes were less immune to the microcin. TolC is thus likely a component of a microcin export complex containing the McjD immunity protein, an ABC exporter.

* Corresponding author. Mailing address: Departamento de Bioquímica de la Nutrición, INSIBIO, Chacabuco 461, 4000 San Miguel de Tucumán, Argentina. Phone: 54-81-248921. Fax: 54-81-248025. E-mail: salomon{at}insibio.unt.edu.ar.

Journal of Bacteriology, March 1999, p. 1968-1970, Vol. 181, No. 6
0021-9193/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.


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