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Journal of Bacteriology, April 1999, p. 2261-2266, Vol. 181, No. 7
0021-9193/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.

Mutational Analysis of the vacA Promoter Provides Insight into Gene Transcription in Helicobacter pylori

Mark H. Forsyth1 and Timothy L. Cover1,2,*

Departments of Medicine and Microbiology and Immunology, Vanderbilt University School of Medicine,1 and Veterans Affairs Medical Center,2 Nashville, Tennessee

Received 29 September 1998/Accepted 20 January 1999

Analysis of 12 Helicobacter pylori promoters indicates the existence of a consensus -10 hexamer (TAtaaT) but little conservation of -35 sequences. In this study, mutations in either the H. pylori vacA -10 region or the -35 region resulted in decreased vacA transcription and suggested that an extended -10 motif is utilized. Thus, despite the lack of a -35 consensus sequence for H. pylori promoters, the -35 region plays a functional role in vacA transcription.

* Corresponding author. Mailing address: Division of Infectious Diseases, A3310 Medical Center North, Vanderbilt University School of Medicine, Nashville TN 37232-2605. Phone: (615) 322-2035. Fax: (615) 343-6160.

Journal of Bacteriology, April 1999, p. 2261-2266, Vol. 181, No. 7
0021-9193/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.


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