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Journal of Bacteriology, April 1999, p. 2273-2278, Vol. 181, No. 7
0021-9193/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.

The Choline-Converting Pathway in Staphylococcus xylosus C2A: Genetic and Physiological Characterization

Ralf Rosenstein,* Detlinde Futter-Bryniok, and Friedrich Götz

Mikrobielle Genetik, Universität Tübingen, 72076 Tübingen, Germany

Received 28 September 1998/Accepted 22 January 1999

A Staphylococcus xylosus C2A gene cluster, which encodes enzymes in the pathway for choline uptake and dehydrogenation (cud), to form the osmoprotectant glycine betaine, was identified. The cud locus comprises four genes, three of which encode proteins with significant similarities to those known to be involved in choline transport and conversion in other organisms. The physiological role of the gene products was confirmed by analysis of cud deletion mutants. The fourth gene possibly codes for a regulator protein. Part of the gene cluster was shown to be transcriptionally regulated by choline and elevated NaCl concentrations as inducers.

* Corresponding author. Mailing address: Mikrobielle Genetik, Universität Tübingen, Waldhäuser Str. 70/8, 72076 Tübingen, Germany. Phone: 49-7071-2975938. Fax: 49-7071-295937. E-mail: ralf.rosenstein{at}uni-tuebingen.de.

Journal of Bacteriology, April 1999, p. 2273-2278, Vol. 181, No. 7
0021-9193/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.


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  • Cánovas, D., Vargas, C., Kneip, S., Morón, M.-J., Ventosa, A., Bremer, E., Nieto, J. J. (2000). Genes for the synthesis of the osmoprotectant glycine betaine from choline in the moderately halophilic bacterium Halomonas elongata DSM 3043. Microbiology 146: 455-463 [Abstract] [Full Text]  


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