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Journal of Bacteriology, April 1999, p. 2273-2278, Vol. 181, No. 7
Mikrobielle Genetik, Universität
Tübingen, 72076 Tübingen, Germany
Received 28 September 1998/Accepted 22 January 1999
A Staphylococcus xylosus C2A gene cluster, which
encodes enzymes in the pathway for choline uptake and dehydrogenation
(cud), to form the osmoprotectant glycine betaine, was
identified. The cud locus comprises four genes, three of
which encode proteins with significant similarities to those known to
be involved in choline transport and conversion in other organisms. The
physiological role of the gene products was confirmed by analysis of
cud deletion mutants. The fourth gene possibly codes for a
regulator protein. Part of the gene cluster was shown to be
transcriptionally regulated by choline and elevated NaCl concentrations
as inducers.
0021-9193/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.
The Choline-Converting Pathway in
Staphylococcus xylosus C2A: Genetic and Physiological
Characterization
*
Corresponding author. Mailing address:
Mikrobielle Genetik, Universität Tübingen,
Waldhäuser Str. 70/8, 72076 Tübingen, Germany. Phone:
49-7071-2975938. Fax: 49-7071-295937. E-mail: ralf.rosenstein{at}uni-tuebingen.de.
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