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 Previous Article

Journal of Bacteriology, May 1999, p. 2984-2986, Vol. 181, No. 9
0021-9193/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.

Isolation and Characterization of the Saccharomyces cerevisiae XPT1 Gene Encoding Xanthine Phosphoribosyl Transferase

M. L. Guetsova,1 T. R. Crother,2 M. W. Taylor,2 and B. Daignan-Fornier1,*

Institut de Biochimie et Génétique Cellulaires, CNRS UPR9026, F-33077 Bordeaux Cedex, France,1 and Department of Biology, Indiana University, Bloomington, Indiana 474052

Received 25 January 1999/Accepted 26 February 1999

A new Saccharomyces cerevisiae gene, XPT1, was isolated as a multicopy suppressor of a hypoxanthine phosphoribosyl transferase (HPRT) defect. Disruption of XPT1 affects xanthine utilization in vivo and results in a severe reduction of xanthine phosphoribosyl transferase (XPRT) activity while HPRT is unaffected. We conclude that XPT1 encodes XPRT in yeast.

* Corresponding author. Mailing address: IBGC CNRS UPR9026, 1, rue Camille Saint-Saëns, 33077 Bordeaux Cedex, France. Phone: 33 5 56 99 90 55. Fax: 33 5 56 99 90 59. E-mail: B.Daignan-Fornier{at}ibgc.u-bordeaux2.fr.

Journal of Bacteriology, May 1999, p. 2984-2986, Vol. 181, No. 9
0021-9193/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.


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