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Journal of Bacteriology, January 2000, p. 207-210, Vol. 182, No. 1
0021-9193/0/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.

Localized Reversible Frameshift Mutation in the flhA Gene Confers Phase Variability to Flagellin Gene Expression in Campylobacter coli

Simon F. Park,1,* Desmond Purdy,2 and Stephen Leach2

School of Biological Sciences, University of Surrey, Guildford, GU2 5XH,1 and Centre for Applied Microbiology and Research, Porton Down, Salisbury, SP4 OJG,2 United Kingdom

Received 3 August 1999/Accepted 14 October 1999

Phase variation of flagellin gene expression in Campylobacter coli UA585 was correlated with high-frequency, reversible insertion and deletion frameshift mutations in a short homopolymeric tract of thymine residues located in the N-terminal coding region of the flhA gene. Mutation-based phase variation in flhA may generate functional diversity in the host and environment.

* Corresponding author. Mailing address: School of Biological Sciences, University of Surrey, Guildford, GU2 5XH, United Kingdom. Phone: 44 (0)1483 879024. Fax: 44 (0)1483 300374. E-mail: s.park{at}surrey.ac.uk.

Journal of Bacteriology, January 2000, p. 207-210, Vol. 182, No. 1
0021-9193/0/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.


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