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Journal of Bacteriology, January 2000, p. 225-227, Vol. 182, No. 1
0021-9193/0/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.

Inorganic Polyphosphate Is Required for Motility of Bacterial Pathogens

M. Harunur Rashid, Narayana N. Rao, and Arthur Kornberg*

Department of Biochemistry, Stanford University School of Medicine, Stanford, California 94305

Received 19 April 1999/Accepted 11 October 1999

The ppk gene encodes polyphosphate kinase (PPK), the principal enzyme in many bacteria responsible for the synthesis of inorganic polyphosphate (polyP) from ATP. A null mutation in the ppk gene of six bacterial pathogens renders them greatly impaired in motility on semisolid agar plates; this defect can be corrected by the introduction of ppk gene in trans. In view of the fact that the motility of pathogens is essential to invade and establish systemic infections in host cells, this impairment in motility suggests a crucial and essential role of PPK or polyP in bacterial pathogenesis.

* Corresponding author. Mailing address: Department of Biochemistry, Stanford University School of Medicine, Stanford, CA 94305. Phone: (650) 723-6167. Fax: (650) 723-6783. E-mail: akornber{at}cmgm.stanford.edu.

Journal of Bacteriology, January 2000, p. 225-227, Vol. 182, No. 1
0021-9193/0/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.


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