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Journal of Bacteriology, January 2000, p. 233-235, Vol. 182, No. 1
0021-9193/0/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.

Metabolite Repression and Inducer Exclusion in the Proline Utilization Gene Cluster of Aspergillus nidulans

Beatriz Cubero,dagger Dennis Gómez, and Claudio Scazzocchio*

Institut de Génétique et Microbiologie, Université Paris-Sud, UMR CNRS C8621, 91405 Orsay Cedex, France

Received 29 July 1999/Accepted 8 October 1999

The clustered prnB, prnC, and prnD genes are repressed by the simultaneous presence of glucose and ammonium. A derepressed mutation inactivating a CreA-binding site acts in cis only on the permease gene (prnB) while derepression of prnD and prnC is largely the result of reversal of inducer exclusion.

* Corresponding author. Mailing address: Institut de Génétique et Microbiologie, Université Paris-Sud, Bâtiment 409, UMR CNRS C8621, 91405 Orsay Cedex, France. Phone: 33-01-69-15-63-56. Fax: 33-01-69-15-57-08. E-mail: scazzochio{at}igmors.u-psud.fr.

dagger Present address: Departamento de Genetica, Universidad de Sevilla, Sevilla 41080, Spain.

Journal of Bacteriology, January 2000, p. 233-235, Vol. 182, No. 1
0021-9193/0/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.


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