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Journal of Bacteriology, June 2000, p. 3210-3218, Vol. 182, No. 11
0021-9193/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.
Differences in Genotypes of Helicobacter
pylori from Different Human Populations
Dangeruta
Kersulyte,1
Asish K.
Mukhopadhyay,1
Billie
Velapatiño,1,2
WanWen
Su,1
ZhiJun
Pan,1
Claudia
Garcia,1,3
Virginia
Hernandez,1
Yanet
Valdez,1,2
Rajesh S.
Mistry,1,4
Robert H.
Gilman,2
Yuan
Yuan,1,5
Hua
Gao,1,5
Teresa
Alarcón,6
Manuel
López-Brea,6
G.
Balakrish
Nair,7
Abhijit
Chowdhury,7
Simanti
Datta,7
Mutsunori
Shirai,8
Teruko
Nakazawa,8
Reidwaan
Ally,4
Isidore
Segal,4
Benjamin C. Y.
Wong,9
S. K.
Lam,9
Farzad O.
Olfat,10,11
Thomas
Borén,10
Lars
Engstrand,11
Olga
Torres,3
Roberto
Schneider,3
Julian E.
Thomas,12
Steven
Czinn,13 and
Douglas
E.
Berg1,*
Departments of Molecular Microbiology and
Genetics, Washington University Medical School, St. Louis, Missouri
631101; Department of Pathology,
Universidad Peruana Cayetano Heredia, Lima,
Peru2; Instituto de Nutricion de
Centroamerica y Panama, Guatemala City, Guatemala
090013; Division of Gastroenterology,
Chris Hani Baragawanath Hospital, Johannesburg 2013, South
Africa4; Cancer Institute, China Medical
University, Shenyang,5 and Department of
Medicine, Queen Mary Hospital, University of Hong Kong, Hong
Kong,9 China; Department of
Microbiology, Hospital Universitario de la Princesa, Madrid,
Spain6; National Institute of Cholera
and Enteric Diseases, Calcutta-700010, India7;
Department of Microbiology, Yamaguchi University School of
Medicine, Ube, Yamaguchi 755, Japan8;
Department of Odontology, Umea University, SE-901 85 Umea,10 and Swedish Institute for
Infectious Disease Control, SE-171 82 Solna,11
Sweden; Sir James Spence Institute of Child Health, The Royal
Victoria Infirmary, Newcastle upon Tyne, United
Kingdom12; and Division of
Gastroenterology, Childrens Hospital, Case Western Reserve Medical
School, Cleveland, Ohio 4410613
Received 19 January 2000/Accepted 15 March 2000
DNA motifs at several informative loci in more than 500 strains of
Helicobacter pylori from five continents were studied by PCR and sequencing to gain insights into the evolution of this gastric
pathogen. Five types of deletion, insertion, and substitution motifs
were found at the right end of the H. pylori cag
pathogenicity island. Of the three most common motifs, type I
predominated in Spaniards, native Peruvians, and Guatemalan
Ladinos (mixed Amerindian-European ancestry) and also in native
Africans and U.S. residents; type II predominated among Japanese and
Chinese; and type III predominated in Indians from Calcutta. Sequences
in the cagA gene and in vacAm1 type alleles of
the vacuolating cytotoxin gene (vacA) of strains from
native Peruvians were also more like those from Spaniards than those
from Asians. These indications of relatedness of Latin American and
Spanish strains, despite the closer genetic relatedness of Amerindian
and Asian people themselves, lead us to suggest that H. pylori may have been brought to the New World by European conquerors and colonists about 500 years ago. This thinking, in turn,
suggests that H. pylori infection might have become
widespread in people quite recently in human evolution.
*
Corresponding author. Mailing address: Department of
Molecular Microbiology, Campus Box 8230, Washington University Medical School, 4566 Scott Ave., St. Louis, MO 63110. Phone: (314) 362-2772. Fax: (314) 362-1232 or -3203. E-mail:
berg{at}borcim.wustl.edu.
Journal of Bacteriology, June 2000, p. 3210-3218, Vol. 182, No. 11
0021-9193/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.
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Copyright © 2000 by the American Society for Microbiology. All rights reserved.