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Journal of Bacteriology, June 2000, p. 3310-3313, Vol. 182, No. 11
The Howard Hughes Medical Institute,
Department of Molecular Biology and Genetics, The Johns Hopkins
University School of Medicine, Baltimore, Maryland 21205
Received 29 October 1999/Accepted 14 March 2000
The bacterial transposon Tn7 inserts at high frequency
into a specific site called attTn7, which is
present in the chromosomes of many bacteria. We show here that
transcription of a nearby gene, glmS, decreases the
frequency of Tn7 insertion into
attTn7, thus providing a link between
Tn7 transposition and host cell metabolism.
0021-9193/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.
Target Site Selection by Tn7:
attTn7 Transcription and Target
Activity
and
*
Corresponding author. Mailing address: The Howard
Hughes Medical Institute, Department of Molecular Biology and Genetics, The Johns Hopkins University School of Medicine, 725 N. Wolfe St., 601 PCTB, Baltimore, MD 21205. Phone: (410) 955-3933. Fax: (410) 955-0831. E-mail: ncraig{at}jhmi.edu.
Present address: The Institute for Genomic Research, Rockville, MD 20850.
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