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Journal of Bacteriology, June 2000, p. 3590-3592, Vol. 182, No. 12
0021-9193/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.

In Vivo Splicing and Functional Characterization of Mycobacterium leprae RecA

Klaus Frischkorn,1 Burkhard Springer,1 Erik C. Böttger,1 Elaine O. Davis,2 M. Joseph Colston,2 and Peter Sander1,2,*

Medizinische Hochschule Hannover, Institut für Medizinische Mikrobiologie, 30625 Hannover, Germany,1 and Division of Mycobacterial Research, National Institute for Medical Research, London NW7 1AA, United Kingdom2

Received 1 December 1999/Accepted 21 March 2000

The RecA proteins from Mycobacterium tuberculosis and Mycobacterium leprae contain inteins. In contrast to the M. tuberculosis RecA, the M. leprae RecA is not spliced in Escherichia coli. We demonstrate here that M. leprae RecA is functionally spliced in Mycobacterium smegmatis and produces resistance toward DNA-damaging agents and homologous recombination.

* Corresponding author. Mailing address: Medizinische Hochschule Hannover, Institut für Medizinische Mikrobiologie, Carl-Neuberg-Straße 1, 30625 Hannover, Germany. Phone: 49-511-532 4361. Fax: 49-511-532 4366. E-mail: sander.peter{at}mh-hannover.de.

Journal of Bacteriology, June 2000, p. 3590-3592, Vol. 182, No. 12
0021-9193/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.




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