Phosphorelay as the Sole Physiological Route of Signal Transmission by the Arc Two-Component System of Escherichia coli

doi:10.1128/JB.182.13.3858-3862.2000

This Article

	Full Text
	Full Text (PDF)
	Alert me when this article is cited
	Alert me if a correction is posted

Services

	Similar articles in this journal
	Similar articles in PubMed
	Alert me to new issues of the journal
	Download to citation manager
	Reprints and Permissions
	Copyright Information
	Books from ASM Press
	MicrobeWorld

Citing Articles

	Citing Articles via HighWire
	Citing Articles via Google Scholar

Google Scholar

	Articles by Kwon, O.
	Articles by Lin, E. C. C.
	Search for Related Content

PubMed

	PubMed Citation
	Articles by Kwon, O.
	Articles by Lin, E. C. C.

Journal of Bacteriology, July 2000, p. 3858-3862, Vol. 182, No. 13
0021-9193/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.

Phosphorelay as the Sole Physiological Route of Signal Transmission by the Arc Two-Component System of Escherichia coli

Ohsuk Kwon, Dimitris Georgellis, and E. C. C. Lin^*

Department of Microbiology and Molecular Genetics, Harvard Medical School, Boston, Massachusetts 02115

Received 7 February 2000/Accepted 11 April 2000

The Arc two-component system, comprising a tripartite sensor kinase (ArcB) and a response regulator (ArcA), modulates theexpression of numerous genes involved in respiratory functions.In this study, the steps of phosphoryl group transfer from phosphorylatedArcB to ArcA were examined in vivo by using single copies of wild-typeand mutant arcB alleles. The results indicate that the signaltransmission occurs solely by His-Asp-His-Aspphosphorelay.

^* Corresponding author. Mailing address: Department of Microbiology and Molecular Genetics, Harvard Medical School, 200 LongwoodAve., Boston, MA 02115. Phone: (617) 432-1925. Fax: (617) 738-7664.E-mail: elin{at}hms.harvard.edu.

Journal of Bacteriology, July 2000, p. 3858-3862, Vol. 182, No. 13
0021-9193/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.

This article has been cited by other articles:

Geszvain, K., Visick, K. L. (2008). The Hybrid Sensor Kinase RscS Integrates Positive and Negative Signals To Modulate Biofilm Formation in Vibrio fischeri. J. Bacteriol. 190: 4437-4446 [Abstract] [Full Text]
He, Y.-W., Wang, C., Zhou, L., Song, H., Dow, J. M., Zhang, L.-H. (2006). Dual Signaling Functions of the Hybrid Sensor Kinase RpfC of Xanthomonas campestris Involve Either Phosphorelay or Receiver Domain-Protein Interaction. J. Biol. Chem. 281: 33414-33421 [Abstract] [Full Text]
Nikel, P. I., Pettinari, M. J., Galvagno, M. A., Mendez, B. S. (2006). Poly(3-Hydroxybutyrate) Synthesis by Recombinant Escherichia coli arcA Mutants in Microaerobiosis. Appl. Environ. Microbiol. 72: 2614-2620 [Abstract] [Full Text]
Pena-Sandoval, G. R., Kwon, O., Georgellis, D. (2005). Requirement of the Receiver and Phosphotransfer Domains of ArcB for Efficient Dephosphorylation of Phosphorylated ArcA In Vivo. J. Bacteriol. 187: 3267-3272 [Abstract] [Full Text]
Jeong, J.-Y., Kim, Y.-J., Cho, N., Shin, D., Nam, T.-W., Ryu, S., Seok, Y.-J. (2004). Expression of ptsG Encoding the Major Glucose Transporter Is Regulated by ArcA in Escherichia coli. J. Biol. Chem. 279: 38513-38518 [Abstract] [Full Text]
Malpica, R., Franco, B., Rodriguez, C., Kwon, O., Georgellis, D. (2004). Identification of a quinone-sensitive redox switch in the ArcB sensor kinase. Proc. Natl. Acad. Sci. USA 101: 13318-13323 [Abstract] [Full Text]
Tomich, M., Mohr, C. D. (2004). Genetic Characterization of a Multicomponent Signal Transduction System Controlling the Expression of Cable Pili in Burkholderia cenocepacia. J. Bacteriol. 186: 3826-3836 [Abstract] [Full Text]
Rodriguez, C., Kwon, O., Georgellis, D. (2004). Effect of D-Lactate on the Physiological Activity of the ArcB Sensor Kinase in Escherichia coli. J. Bacteriol. 186: 2085-2090 [Abstract] [Full Text]
Sengupta, N., Paul, K., Chowdhury, R. (2003). The Global Regulator ArcA Modulates Expression of Virulence Factors in Vibrio cholerae. Infect. Immun. 71: 5583-5589 [Abstract] [Full Text]
Kwon, O., Georgellis, D., Lin, E. C. C. (2003). Rotational On-off Switching of a Hybrid Membrane Sensor Kinase Tar-ArcB in Escherichia coli. J. Biol. Chem. 278: 13192-13195 [Abstract] [Full Text]
Suzuki, K., Wang, X., Weilbacher, T., Pernestig, A.-K., Melefors, O., Georgellis, D., Babitzke, P., Romeo, T. (2002). Regulatory Circuitry of the CsrA/CsrB and BarA/UvrY Systems of Escherichia coli. J. Bacteriol. 184: 5130-5140 [Abstract] [Full Text]
Georgellis, D., Kwon, O., Lin, E. C. C., Wong, S. M., Akerley, B. J. (2001). Redox Signal Transduction by the ArcB Sensor Kinase of Haemophilus influenzae Lacking the PAS Domain. J. Bacteriol. 183: 7206-7212 [Abstract] [Full Text]
Georgellis, D., Kwon, O., Lin, E. C. C. (2001). Quinones as the Redox Signal for the Arc Two-Component System of Bacteria. Science 292: 2314-2316 [Abstract] [Full Text]
Ansaldi, M., Jourlin-Castelli, C., Lepelletier, M., Théraulaz, L., Méjean, V. (2001). Rapid Dephosphorylation of the TorR Response Regulator by the TorS Unorthodox Sensor in Escherichia coli. J. Bacteriol. 183: 2691-2695 [Abstract] [Full Text]
Jeon, Y., Lee, Y. S., Han, J. S., Kim, J. B., Hwang, D. S. (2001). Multimerization of Phosphorylated and Non-phosphorylated ArcA Is Necessary for the Response Regulator Function of the Arc Two-component Signal Transduction System. J. Biol. Chem. 276: 40873-40879 [Abstract] [Full Text]

Appl. Environ. Microbiol.	Infect. Immun.	Eukaryot. Cell
Mol. Cell. Biol.	J. Virol.	Microbiol. Mol. Biol. Rev.
	ALL ASM JOURNALS