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Journal of Bacteriology, July 2000, p. 3874-3876, Vol. 182, No. 13
0021-9193/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.

Phosphorylated PmrA Interacts with the Promoter Region of ugd in Salmonella enterica Serovar Typhimurium

Andrés Aguirre, Sergio Lejona, Eleonora García Véscovi, and Fernando C. Soncini*

Departamento de Microbiología, Facultad de Ciencias Bioquímicas y Farmacéuticas, Universidad Nacional de Rosario, Rosario, Argentina

Received 10 January 2000/Accepted 14 April 2000

The Salmonella PmrA-PmrB system controls the expression of genes necessary for polymyxin B resistance. Four loci were previously identified as part of the regulon, and interaction of PmrA with the promoter region of three of them was observed. Here we characterized the interaction of PmrA with the promoter region of ugd, previously suggested to be regulated indirectly by PmrA. Our results indicate that PmrA controls the expression of ugd by interacting with a specific sequence in the promoter region of this gene.

* Corresponding author. Mailing address: Facultad de Ciencias Bioquímicas y Farmacéuticas (UNR), Departamento de Microbiología, Suipacha 531, (2000) Rosario, Argentina. Phone: 54-341-4370008. Fax: 54-341-4804598. E-mail: pat-bact{at}citynet.net.ar.

Journal of Bacteriology, July 2000, p. 3874-3876, Vol. 182, No. 13
0021-9193/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.


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