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Journal of Bacteriology, July 2000, p. 4117-4120, Vol. 182, No. 14
0021-9193/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.

SprE Levels Are Growth Phase Regulated in a sigma S-Dependent Manner at the Level of Translation

Katherine E. Gibson and Thomas J. Silhavy*

Department of Molecular Biology, Princeton University, Princeton, New Jersey 08544

Received 20 December 1999/Accepted 26 April 2000

SprE regulates sigma S levels in response to nutrient availability by promoting ClpXP-mediated degradation. Paradoxically, we observe that SprE is similarly regulated, accumulating preferentially upon starvation. This regulation of SprE levels is sigma S dependent, altering SprE synthesis at the level of translation. Thus, we demonstrate that SprE and sigma S function within a regulatory feedback loop.

* Corresponding author. Mailing address: Department of Molecular Biology, Princeton University, Princeton, NJ 08544. Phone: (609) 258-5899. Fax: (609) 258-2957. E-mail: tsilhavy{at}molbio.princeton.edu.

Journal of Bacteriology, July 2000, p. 4117-4120, Vol. 182, No. 14
0021-9193/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.


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