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Journal of Bacteriology, August 2000, p. 4257-4263, Vol. 182, No. 15
0021-9193/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.

Transcriptional Analysis of Major Heat Shock Genes of Helicobacter pylori

Georg Homuth,1 Stephanie Domm,2 Diethelm Kleiner,2 and Wolfgang Schumann1,*

Institute of Genetics1 and Institute of Microbiology,2 University of Bayreuth, D-95440 Bayreuth, Germany

Received 15 February 2000/Accepted 8 May 2000

The transcriptional organization and heat inducibility of the major heat shock genes hrcA, dnaK, dnaJ, groEL, and htpG were analyzed on the transcriptional level in Helicobacter pylori strain 69A. The strongly heat-induced dnaK operon was found to be tricistronic, consisting of the genes hrcA, grpE, and dnaK. The dnaJ gene specified one monocistronic mRNA which was also heat inducible. The genes groES and groEL were transcribed as one strongly heat-inducible bicistronic mRNA which exhibited exactly the same induction kinetic as the dnaK operon. Surprisingly, transcription of the monocistronic htpG gene was switched off after heat shock. The data presented are discussed with regard to the different mechanisms regulating expression of heat shock genes in H. pylori

* Corresponding author. Mailing address: Institute of Genetics, University of Bayreuth, D-95440 Bayreuth, Germany. Phone: 49 (0)921-552708. Fax: 49 (0)921-552710. E-mail: wolfgang.schumann{at}uni-bayreuth.de.

Journal of Bacteriology, August 2000, p. 4257-4263, Vol. 182, No. 15
0021-9193/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.


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