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Journal of Bacteriology, September 2000, p. 4987-4991, Vol. 182, No. 17
0021-9193/00/$04.00+0

Properties of Various RHO1 Mutant Alleles of Cryptococcus neoformans

Yun C. Chang* and Lisa A. Penoyer

Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892

Received 6 April 2000/Accepted 1 June 2000

The RHO1 homologue of Cryptococcus neoformans complemented Saccharomyces cerevisiae rho1 mutations. The results of overexpression and site-specific mutagenesis of CnRHO1 in C. neoformans and S. cerevisiae indicated that although CnRHO1 could functionally substitute for the RHO1 gene of S. cerevisiae, mutants of cnrho1 manifested unique features in certain aspects.

* Corresponding author. Mailing address: Building 10, Room 11C304, National Institutes of Health, Bethesda, MD 20892. Phone: (301) 496-1238. Fax: (301) 402-1003. E-mail: yc3z{at}nih.gov.

Journal of Bacteriology, September 2000, p. 4987-4991, Vol. 182, No. 17
0021-9193/00/$04.00+0


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