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Journal of Bacteriology, October 2000, p. 5600-5605, Vol. 182, No. 19
0021-9193/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.

IS1675, a Novel Lactococcal Insertion Element, Forms a Transposon-Like Structure Including the Lacticin 481 Lantibiotic Operon

Alain Dufour,1,* Alain Rincé,2 Patricia Uguen,1 and Jean-Paul Le Pennec1

Laboratoire de Biologie et Chimie Moléculaires, EA 2594, Université de Bretagne Sud, Vannes,1 and Laboratoire de Microbiologie de l'Environnement, I.R.B.A., Université de Caen, Caen,2 France

Received 18 January 2000/Accepted 4 July 2000

Two copies of IS1675, a novel lactococcal insertion element from the IS4 family, are present on a 70-kb plasmid, where they frame the lantibiotic lacticin 481 operon. The whole structure could be a composite transposon designated Tn5721. This study shows that the lacticin 481 operon does not include any regulatory gene and provides a new example of a transposon-associated bacteriocin determinant. We identified five other IS1675 copies not associated with the lacticin 481 operon. The conservation of IS1675 flanking sequences suggested a 24-bp target site.

* Corresponding author. Mailing address: LBCM, UBS, Ave. de Tohannic, 56000 Vannes, France. Phone: (33)-2-97-68-31-93. Fax: (33)-2-97-68-16-39. E-mail: alain.dufour{at}univ-ubs.fr.

Journal of Bacteriology, October 2000, p. 5600-5605, Vol. 182, No. 19
0021-9193/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.


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