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Journal of Bacteriology, October 2000, p. 5631-5633, Vol. 182, No. 19
Department of Zoology and Genetics, Iowa
State University, Ames, Iowa 50011
Received 3 February 2000/Accepted 26 June 2000
We report the cloning and sequencing of the Brucella abortus
oxyR homolog and provide evidence that the transcription product of this gene binds to the B. abortus catalase promoter
region. A gene replacement/deletion Brucella oxyR mutant
exhibits increased sensitivity to prolonged exposure to
H2O2 and is unable to adapt to
H2O2 in the environment.
0021-9193/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.
Identification of Brucella abortus OxyR
and Its Role in Control of Catalase Expression
and
*
Corresponding author. Mailing address: Department of
Zoology and Genetics, 2106 Molecular Biology Building, Iowa State
University, Ames, IA 50011. Phone: (515) 294-1170. Fax: (515) 294-3003. E-mail: jemayf{at}iastate.edu.
Present address: Department of Ophthalmology and Visual Science,
College of Medicine, The Catholic University of Korea, and Catholic
Research Institute of Medical Sciences, 505, Banpo-dong, Seocho-ku,
Seoul, Korea.
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