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Journal of Bacteriology, October 2000, p. 5631-5633, Vol. 182, No. 19
0021-9193/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.

Identification of Brucella abortus OxyR and Its Role in Control of Catalase Expression

Jeong-a Kimdagger and John Mayfield*

Department of Zoology and Genetics, Iowa State University, Ames, Iowa 50011

Received 3 February 2000/Accepted 26 June 2000

We report the cloning and sequencing of the Brucella abortus oxyR homolog and provide evidence that the transcription product of this gene binds to the B. abortus catalase promoter region. A gene replacement/deletion Brucella oxyR mutant exhibits increased sensitivity to prolonged exposure to H2O2 and is unable to adapt to H2O2 in the environment.

* Corresponding author. Mailing address: Department of Zoology and Genetics, 2106 Molecular Biology Building, Iowa State University, Ames, IA 50011. Phone: (515) 294-1170. Fax: (515) 294-3003. E-mail: jemayf{at}iastate.edu.

dagger Present address: Department of Ophthalmology and Visual Science, College of Medicine, The Catholic University of Korea, and Catholic Research Institute of Medical Sciences, 505, Banpo-dong, Seocho-ku, Seoul, Korea.

Journal of Bacteriology, October 2000, p. 5631-5633, Vol. 182, No. 19
0021-9193/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.


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