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Journal of Bacteriology, January 2000, p. 536-539, Vol. 182, No. 2
0021-9193/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.

The Feedback Response of Escherichia coli rRNA Synthesis Is Not Identical to the Mechanism of Growth Rate-Dependent Control

Justina Voulgaris,1 Dmitry Pokholok,2,dagger W. Mike Holmes,2 Craig Squires,3 and Catherine L. Squires3,*

Department of Biological Sciences, Columbia University, New York, New York 100271; Department of Microbiology & Immunology, Medical College of Virginia Campus of Virginia Commonwealth University, Richmond, Virginia 232982; and Department of Molecular Biology and Microbiology, Tufts University School of Medicine, Boston, Massachusetts3

Received 13 July 1999/Accepted 27 October 1999

Growth rate-independent rrn P1 promoter mutants were tested for their ability to respond to changes in rrn gene dosage. Most were found to be normal for the feedback response. In addition, cellular levels of the initiating nucleoside triphosphates remained unchanged when the rrn gene dosage was altered. These results suggest that the feedback response cannot be the mechanism for growth rate-dependent control of rRNA synthesis and that the relationship between these two processes may be more complicated than is currently understood.

* Corresponding author. Mailing address: Department of Molecular Biology and Microbiology, Tufts University School of Medicine, 136 Harrison Ave., Boston, MA 02111. Phone: (617) 636-6947. Fax: (617) 636-0337. E-mail: csquires_rib{at}opal.tufts.edu.

dagger Present address: Whitehead Institute/MIT, Cambridge, MA 02142.

Journal of Bacteriology, January 2000, p. 536-539, Vol. 182, No. 2
0021-9193/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.


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