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Journal of Bacteriology, October 2000, p. 5898-5901, Vol. 182, No. 20
0021-9193/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.

Null Mutation of the dam or seqA Gene Suppresses Temperature-Sensitive Lethality but Not Hypersensitivity to Novobiocin of muk Null Mutants

Toshinari Onogi, Mitsuyoshi Yamazoe, Chiyome Ichinose, Hironori Niki, and Sota Hiraga*

Department of Molecular Cell Biology, Institute of Molecular Embryology and Genetics, Kumamoto University, Kumamoto 862-0976, Japan

Received 19 August 1999/Accepted 14 July 2000

Escherichia coli mukF, mukE, and mukB null mutants have common phenotypes such as temperature-dependent colony formation, anucleate cell production, chromosome cutting by septum closure, and abnormal localization of SeqA-DNA clusters. We show here that the associated muk null mutations cause hypersensitivity to novobiocin. Null mutation of either dam or seqA suppressed partially the temperature-sensitive lethality but failed to suppress the anucleate cell production and the hypersensitivity to novobiocin caused by muk null mutations.

* Corresponding author. Mailing address: Department of Molecular Cell Biology, Institute of Molecular Embryology and Genetics, Kumamoto University, Kuhonji 4-24-1, Kumamoto 862-0976, Japan. Phone: 81-96-373-6578. Fax: 81-96-373-6582. E-mail: hiraga{at}gpo.kumamoto-u.ac.jp.

Journal of Bacteriology, October 2000, p. 5898-5901, Vol. 182, No. 20
0021-9193/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.


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