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Journal of Bacteriology, October 2000, p. 5902-5905, Vol. 182, No. 20
0021-9193/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.

New Virulence-Activated and Virulence-Repressed Genes Identified by Systematic Gene Inactivation and Generation of Transcriptional Fusions in Bordetella pertussis

Rudy Antoine, Sylvie Alonso, Dominique Raze, Loïc Coutte, Sarah Lesjean, Eve Willery, Camille Locht, and Françoise Jacob-Dubuisson*

INSERM U447, Institut de Biologie de Lille, Institut Pasteur de Lille, 59019 Lille Cedex, France

Received 1 May 2000/Accepted 24 July 2000

An in silico scan of the partially completed genome sequence of Bordetella pertussis and analyses of transcriptional fusions generated with a new integrational vector were used to identify new potential virulence genes. The genes encoding a putative siderophore receptor, adhesins, and an autotransporter protein appeared to be regulated in a manner similar to Bordetella virulence genes by the global virulence regulator BvgAS. In contrast, the gene encoding a putative intimin-like protein appeared to be repressed under conditions of virulence.

* Corresponding author. Mailing address: INSERM U447, Institut de Biologie de Lille, Institut Pasteur de Lille, 1 rue Calmette, 59019 Lille Cedex, France. Phone: 33 3 20 87 11 55. Fax: 33 3 20 87 11 58. E-mail: francoise.jacob{at}pasteur-lille.fr.

Journal of Bacteriology, October 2000, p. 5902-5905, Vol. 182, No. 20
0021-9193/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.


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