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Journal of Bacteriology, November 2000, p. 6228-6232, Vol. 182, No. 21
0021-9193/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.

Vancomycin Resistance Is Associated with Serine-Containing Peptidoglycan in Enterococcus gallinarum

Patrick Grohs,1 Laurent Gutmann,1 Raymond Legrand,2 Bernard Schoot,2 and Jean Luc Mainardi1,*

Laboratoire de Recherche Moléculaire sur les Antibiotiques, UFR Broussais-Hôtel Dieu, Université Paris VI, Paris,1 and Physics Department, Hoestch Marion Roussel, Romainville,2 France

Received 22 May 2000/Accepted 4 August 2000

In Enterococcus gallinarum SC1, a low-level vancomycin-resistant strain, only monomeric muropentapeptides with a C-terminal D-alanine were detected after growth without vancomycin. In contrast, in SC1 induced by vancomycin, as well as in AIB39, a constitutive vancomycin-resistant strain, monomeric and dimeric muropentapeptides with a C-terminal D-serine were detected.

* Corresponding author. Mailing address: Laboratoire de Recherche Moléculaire sur les Antibiotiques, (LRMA), UFR Broussais-Hôtel Dieu, Université Paris VI, 15, rue de l'Ecole de Médecine, 75270 Paris Cedex 06, France. Phone: 33-1-42.34.68.63. Fax: 33-1-43.25.68.12. E-mail: jlmainar{at}bhdc.jussieu.fr.

Journal of Bacteriology, November 2000, p. 6228-6232, Vol. 182, No. 21
0021-9193/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.


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