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Journal of Bacteriology, December 2000, p. 6842-6844, Vol. 182, No. 23
0021-9193/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.

Hydrogen Peroxide Activates the SoxRS Regulon In Vivo

Manuel Manchado, Carmen Michán, and Carmen Pueyo*

Departamento de Bioquímica y Biología Molecular, Universidad de Córdoba, 14071 Córdoba, Spain

Received 12 July 2000/Accepted 12 September 2000

By multiplex reverse transcription-PCR, we demonstrate that the SoxRS response, which protects cells against superoxide toxicity, is triggered also by hydrogen peroxide. SoxR-dependent inductions of 7.3-, 7.6-, 4.6-, 2.2-, and 2.6-fold were quantified for soxS, micF, sodA, inaA, and fpr transcripts, respectively. This finding suggests an extensive and tight connectivity between different regulatory pathways in the Escherichia coli response to oxidative stress.

* Corresponding author. Mailing address: Departamento de Bioquímica y Biología Molecular, Campus de Rabanales edificio C-6, Carretera Madrid-Cádiz Km 396-a, Universidad de Córdoba, 14071 Córdoba, Spain. Phone: 34 957 218695. Fax: 34 957 218688. E-mail: bb1pucuc{at}uco.es.

Journal of Bacteriology, December 2000, p. 6842-6844, Vol. 182, No. 23
0021-9193/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.


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