This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Xie, H.
Right arrow Articles by Lamont, R. J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Xie, H.
Right arrow Articles by Lamont, R. J.
Right arrowPubmed/NCBI databases
*Substance via MeSH

 Previous Article  |  Next Article 

Journal of Bacteriology, December 2000, p. 7067-7069, Vol. 182, No. 24
0021-9193/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.

Intergeneric Communication in Dental Plaque Biofilms

Hua Xie,1,* Guy S. Cook,2 J. William Costerton,3 Greg Bruce,4 Timothy M. Rose,4 and Richard J. Lamont5

School of Dentistry, Meharry Medical College, Nashville, Tennessee1; Bacterin Inc.,2 and Center for Biofilm Engineering, Montana State University,3 Bozeman, Montana; and Department of Pathobiology4 and Department of Oral Biology,5 University of Washington, Seattle, Washington

Received 27 June 2000/Accepted 21 September 2000

Dental plaque is a complex biofilm that accretes in a series of discrete steps proceeding from a gram-positive streptococcus-rich biofilm to a structure rich in gram-negative anaerobes. This study investigated information flow between two unrelated plaque bacteria, Streptococcus cristatus and Porphyromonas gingivalis. A surface protein of S. cristatus caused repression of the P. gingivalis fimbrial gene (fimA), as determined by a chromosomal fimA promoter-lacZ reporter construct and by reverse transcription-PCR. Signaling activity was associated with a 59-kDa surface protein of S. cristatus and showed specificity for the fimA gene. Furthermore, P. gingivalis was unable to form biofilm microcolonies with S. cristatus. Thus, S. cristatus is capable of modulating virulence gene expression in P. gingivalis, consequently influencing the development of pathogenic plaque.

* Corresponding author. Mailing address: School of Dentistry, Meharry Medical College, Nashville, TN 37208. Phone: (615) 327-5981. Fax: (615) 327-5959. E-mail: hxie{at}mail.mmc.edu.

Journal of Bacteriology, December 2000, p. 7067-7069, Vol. 182, No. 24
0021-9193/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.


This article has been cited by other articles:

  • Periasamy, S., Kolenbrander, P. E. (2009). Mutualistic Biofilm Communities Develop with Porphyromonas gingivalis and Initial, Early, and Late Colonizers of Enamel. J. Bacteriol. 191: 6804-6811 [Abstract] [Full Text]  
  • Nobbs, A. H., Lamont, R. J., Jenkinson, H. F. (2009). Streptococcus Adherence and Colonization. Microbiol. Mol. Biol. Rev. 73: 407-450 [Abstract] [Full Text]  
  • Lin, X., Lamont, R. J., Wu, J., Xie, H. (2008). Role of Differential Expression of Streptococcal Arginine Deiminase in Inhibition of fimA Expression in Porphyromonas gingivalis. J. Bacteriol. 190: 4367-4371 [Abstract] [Full Text]  
  • Jakubovics, N. S., Gill, S. R., Iobst, S. E., Vickerman, M. M., Kolenbrander, P. E. (2008). Regulation of Gene Expression in a Mixed-Genus Community: Stabilized Arginine Biosynthesis in Streptococcus gordonii by Coaggregation with Actinomyces naeslundii. J. Bacteriol. 190: 3646-3657 [Abstract] [Full Text]  
  • Xie, H., Lin, X., Wang, B.-Y., Wu, J., Lamont, R. J. (2007). Identification of a signalling molecule involved in bacterial intergeneric communication. Microbiology 153: 3228-3234 [Abstract] [Full Text]  
  • Teughels, W., Kinder Haake, S., Sliepen, I., Pauwels, M., Van Eldere, J., Cassiman, J.-J., Quirynen, M. (2007). Bacteria Interfere with A. actinomycetemcomitans Colonization. JDR 86: 611-617 [Abstract] [Full Text]  
  • Reeser, R. J., Medler, R. T., Billington, S. J., Jost, B. H., Joens, L. A. (2007). Characterization of Campylobacter jejuni Biofilms under Defined Growth Conditions. Appl. Environ. Microbiol. 73: 1908-1913 [Abstract] [Full Text]  
  • Simionato, M. R., Tucker, C. M., Kuboniwa, M., Lamont, G., Demuth, D. R., Tribble, G. D., Lamont, R. J. (2006). Porphyromonas gingivalis Genes Involved in Community Development with Streptococcus gordonii. Infect. Immun. 74: 6419-6428 [Abstract] [Full Text]  
  • Pearson, M. M., Laurence, C. A., Guinn, S. E., Hansen, E. J. (2006). Biofilm Formation by Moraxella catarrhalis In Vitro: Roles of the UspA1 Adhesin and the Hag Hemagglutinin. Infect. Immun. 74: 1588-1596 [Abstract] [Full Text]  
  • Edwards, A. M., Grossman, T. J., Rudney, J. D. (2006). Fusobacterium nucleatum Transports Noninvasive Streptococcus cristatus into Human Epithelial Cells. Infect. Immun. 74: 654-662 [Abstract] [Full Text]  
  • Kreth, J., Merritt, J., Shi, W., Qi, F. (2005). Competition and Coexistence between Streptococcus mutans and Streptococcus sanguinis in the Dental Biofilm. J. Bacteriol. 187: 7193-7203 [Abstract] [Full Text]  
  • Xie, H., Kozlova, N., Lamont, R. J. (2004). Porphyromonas gingivalis Genes Involved in fimA Regulation. Infect. Immun. 72: 651-658 [Abstract] [Full Text]  
  • Kuramitsu, H. K. (2003). MOLECULAR GENETIC ANALYSIS OF THE VIRULENCE OF ORAL BACTERIAL PATHOGENS: AN HISTORICAL PERSPECTIVE. CROBM 14: 331-344 [Abstract] [Full Text]  
  • Nassar, H., Chou, H.-H., Khlgatian, M., Gibson, F. C. III, Dyke, T. E. V., Genco, C. A. (2002). Role for Fimbriae and Lysine-Specific Cysteine Proteinase Gingipain K in Expression of Interleukin-8 and Monocyte Chemoattractant Protein in Porphyromonas gingivalis-Infected Endothelial Cells. Infect. Immun. 70: 268-276 [Abstract] [Full Text]  
  • Palmer, R. J. Jr., Kazmerzak, K., Hansen, M. C., Kolenbrander, P. E. (2001). Mutualism versus Independence: Strategies of Mixed-Species Oral Biofilms In Vitro Using Saliva as the Sole Nutrient Source. Infect. Immun. 69: 5794-5804 [Abstract] [Full Text]  
  • Hooper, L. V., Gordon, J. I. (2001). Commensal Host-Bacterial Relationships in the Gut. Science 292: 1115-1118 [Abstract] [Full Text]  


Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»