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Journal of Bacteriology, December 2000, p. 7075-7077, Vol. 182, No. 24
0021-9193/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.

Transcription Activation by a Variety of AraC/XylS Family Activators Does Not Depend on the Class II-Specific Activation Determinant in the N-Terminal Domain of the RNA Polymerase Alpha Subunit

Susan M. Egan,1,* Andrew J. Pease,2,dagger Jeffrey Lang,2 Xiang Li,2 Vydehi Rao,1 William K. Gillette,3,Dagger Raquel Ruiz,1,4 Juan L. Ramos,4 and Richard E. Wolf Jr.4

Department of Molecular Biosciences, University of Kansas, Lawrence, Kansas 660451; Department of Biological Sciences, University of Maryland Baltimore County, Baltimore, Maryland 212502; and Laboratory of Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892-05603; and Consejo Superior de Investigaciones Cientificas, Estación Experimental del Zaidín, Department of Plant Biochemistry and Molecular and Cellular Biology of Plants, Granada, Spain4

Received 21 August 2000/Accepted 4 October 2000

The N-terminal domain of the RNA polymerase alpha  subunit (alpha -NTD) was tested for a role in transcription activation by a variety of AraC/XylS family members. Based on substitutions at residues 162 to 165 and an extensive genetic screen we conclude that alpha -NTD is not an activation target for these activators.

* Corresponding author. Mailing address: Department of Molecular Biosciences, University of Kansas, Lawrence, KS 66045. Phone: (785) 864-4294. Fax: (785) 864-5294. E-mail: sme{at}ukans.edu.

dagger Present address: Villa Julie College, Stevenson, MD 21153.

Dagger Present address: Life Technologies, Inc., Rockville, MD 20850.

Journal of Bacteriology, December 2000, p. 7075-7077, Vol. 182, No. 24
0021-9193/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.


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