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Journal of Bacteriology, February 2000, p. 833-836, Vol. 182, No. 3
0021-9193/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.

Rapid Turnover of FlhD and FlhC, the Flagellar Regulon Transcriptional Activator Proteins, during Proteus Swarming

Laurent Claret and Colin Hughes*

Department of Pathology, University of Cambridge, Cambridge CB2 1QP, United Kingdom

Received 16 September 1999/Accepted 11 November 1999

The enterobacterial flhDC master operon activates expression of the flagellar biogenesis gene hierarchy and also represses cell division. During Proteus mirabilis differentiation into elongated hyperflagellated swarm cells, flhDC transcription is strongly but transiently increased. We show that concentration of the FlhD and FlhC proteins is also tightly controlled at the posttranslational level. This is achieved by protein degradation, which is most severe after differentiation when the half-life of both proteins is ca. 2 min. Degradation is energy dependent and putatively involves the Lon protease.

* Corresponding author. Mailing address: Department of Pathology, University of Cambridge, Tennis Court Rd., Cambridge CB2 1QP, United Kingdom. Phone and Fax: 44-1223 333732. E-mail: ch{at}mole.bio.cam.ac.uk.

Journal of Bacteriology, February 2000, p. 833-836, Vol. 182, No. 3
0021-9193/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.


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