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Journal of Bacteriology, February 2000, p. 837-841, Vol. 182, No. 3
0021-9193/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.

Sequence Variations within PrfA DNA Binding Sites and Effects on Listeria monocytogenes Virulence Gene Expression

James R. Williams,1 Chetna Thayyullathil,2 and Nancy E. Freitag1,*

Department of Immunology and Microbiology, Wayne State University School of Medicine, Detroit, Michigan,1 and the Public Health Research Institute, New York, New York2

Received 30 June 1999/Accepted 8 November 1999

Reporter gene fusions were used to investigate the contributions of PrfA DNA binding sites to Listeria monocytogenes virulence gene expression. Our results suggest that the DNA sequence of PrfA binding sites determines the levels of expression of certain virulence genes, such as hly and mpl. Other virulence genes, such as actA and plcB, may depend upon additional factors for full regulation of gene expression.

* Corresponding author. Present address: Seattle Biomedical Research Institute, 4 Nickerson St., Seattle, WA 98109-1651. Phone: (206) 284-8846. Fax: (206) 284-0313. E-mail: nfreitag{at}sbri.org.

Journal of Bacteriology, February 2000, p. 837-841, Vol. 182, No. 3
0021-9193/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.


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