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Journal of Bacteriology, March 2000, p. 1427-1431, Vol. 182, No. 5
0021-9193/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.

Requirement for Homologous Recombination Functions for Expression of the mutA Mistranslator tRNA-Induced Mutator Phenotype in Escherichia coli

Li Ren, Abu Amar M. Al Mamun, and M. Zafri Humayun*

Department of Microbiology and Molecular Genetics, University of Medicine and Dentistry of New Jersey---New Jersey Medical School, Newark, New Jersey 07103-2714

Received 19 August 1999/Accepted 23 November 1999

Expression of the Escherichia coli mutA mutator phenotype requires recA, recB, recC, ruvA, and ruvC gene, but not recD, recF, recO, or recR genes. Thus, the recBCD-dependent homologous recombination system is a component of the signal pathway that activates an error-prone DNA polymerase in mutA cells.

* Corresponding author. Mailing address: Department of Microbiology and Molecular Genetics, University of Medicine and Dentistry of New Jersey---New Jersey Medical School, 185 South Orange Ave., MSB-F607, Newark, NJ 07103-2714. Phone: (973) 972-5217. Fax: (973) 972-3644. E-mail: humayun{at}umdnj.edu.

Journal of Bacteriology, March 2000, p. 1427-1431, Vol. 182, No. 5
0021-9193/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.


This article has been cited by other articles:

  • Balashov, S., Humayun, M. Z. (2003). Escherichia coli Cells Bearing a Ribosomal Ambiguity Mutation in rpsD Have a Mutator Phenotype That Correlates with Increased Mistranslation. J. Bacteriol. 185: 5015-5018 [Abstract] [Full Text]  
  • Al Mamun, A. A. M., Marians, K. J., Humayun, M. Z. (2002). DNA Polymerase III from Escherichia coli Cells Expressing mutA Mistranslator tRNA Is Error-prone. J. Biol. Chem. 277: 46319-46327 [Abstract] [Full Text]  
  • Zhao, J., Leung, H.-C. E., Winkler, M. E. (2001). The miaA Mutator Phenotype of Escherichia coli K-12 Requires Recombination Functions. J. Bacteriol. 183: 1796-1800 [Abstract] [Full Text]  


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