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Journal of Bacteriology, March 2000, p. 1432-1436, Vol. 182, No. 5
0021-9193/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.
Novel Missense Mutations That Affect the Transport
Function of MalK, the ATP-Binding-Cassette Subunit of the
Salmonella enterica Serovar Typhimurium Maltose
Transport System
Sabine
Hunke,
Heidi
Landmesser, and
Erwin
Schneider*
Institut für
Biologie/Bakterienphysiologie, Humboldt-Universität zu Berlin,
D-10099 Berlin, Germany
Received 11 August 1999/Accepted 8 December 1999
We report on novel mutations in the malK gene of
Salmonella enterica serovar Typhimurium, encoding the
ATPase subunit of the maltose transporter (MalFGK2).
Biochemical analysis suggests that (i) L86 might be involved in a
signaling step during substrate translocation and (ii) E306 may be
critical for the structural integrity of the protein.
*
Corresponding author. Mailing address:
Humboldt-Universität zu Berlin, Institut für
Biologie/Bakterienphysiologie, Chausseestr. 117, D-10115 Berlin,
Germany. Phone: 49 (0)30-2093-8121. Fax: 49 (0)30-2093-8126. E-mail:
erwin.schneider{at}rz.hu-berlin.de.
Journal of Bacteriology, March 2000, p. 1432-1436, Vol. 182, No. 5
0021-9193/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.
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