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Journal of Bacteriology, March 2000, p. 1761-1763, Vol. 182, No. 6
Institut Jacques Monod,
CNRS-Universités Paris 6 et Paris 7, 75251 Paris Cedex 05, France
Received 11 October 1999/Accepted 20 December 1999
The soxRS response, which protects cells against
superoxide toxicity, is triggered by the oxidation of SoxR, a
transcription factor. Superoxide excess and NADPH depletion induce the
regulon. Unexpectedly, we found that the overproduction of
desulfoferrodoxin, a superoxide reductase from sulfate-reducing
bacteria, also induced this response. We suggest that desulfoferrodoxin
interferes with the reducing pathway that keeps SoxR in its inactive form.
0021-9193/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.
Activation of SoxR by Overproduction of
Desulfoferrodoxin: Multiple Ways To Induce the soxRS
Regulon
*
Corresponding author. Mailing address: Institut Jacques
Monod, CNRS-Universités Paris 6 et Paris 7, 2 place Jussieu,
75251 Paris Cedex 05, France. Phone: 33 1 44 27 47 19. Fax: 33 1 44 27 76 67. E-mail: touatida{at}ccr.jussieu.fr.
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