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Journal of Bacteriology, March 2000, p. 1761-1763, Vol. 182, No. 6
0021-9193/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.

Activation of SoxR by Overproduction of Desulfoferrodoxin: Multiple Ways To Induce the soxRS Regulon

Philippe Gaudu, Sarah Dubrac, and Danièle Touati*

Institut Jacques Monod, CNRS-Universités Paris 6 et Paris 7, 75251 Paris Cedex 05, France

Received 11 October 1999/Accepted 20 December 1999

The soxRS response, which protects cells against superoxide toxicity, is triggered by the oxidation of SoxR, a transcription factor. Superoxide excess and NADPH depletion induce the regulon. Unexpectedly, we found that the overproduction of desulfoferrodoxin, a superoxide reductase from sulfate-reducing bacteria, also induced this response. We suggest that desulfoferrodoxin interferes with the reducing pathway that keeps SoxR in its inactive form.

* Corresponding author. Mailing address: Institut Jacques Monod, CNRS-Universités Paris 6 et Paris 7, 2 place Jussieu, 75251 Paris Cedex 05, France. Phone: 33 1 44 27 47 19. Fax: 33 1 44 27 76 67. E-mail: touatida{at}ccr.jussieu.fr.

Journal of Bacteriology, March 2000, p. 1761-1763, Vol. 182, No. 6
0021-9193/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.


This article has been cited by other articles:

  • Giro, M., Carrillo, N., Krapp, A. R. (2006). Glucose-6-phosphate dehydrogenase and ferredoxin-NADP(H) reductase contribute to damage repair during the soxRS response of Escherichia coli.. Microbiology 152: 1119-1128 [Abstract] [Full Text]  
  • Krapp, A. R., Rodriguez, R. E., Poli, H. O., Paladini, D. H., Palatnik, J. F., Carrillo, N. (2002). The Flavoenzyme Ferredoxin (Flavodoxin)-NADP(H) Reductase Modulates NADP(H) Homeostasis during the soxRS Response of Escherichia coli. J. Bacteriol. 184: 1474-1480 [Abstract] [Full Text]  
  • Manchado, M., Michán, C., Pueyo, C. (2000). Hydrogen Peroxide Activates the SoxRS Regulon In Vivo. J. Bacteriol. 182: 6842-6844 [Abstract] [Full Text]  


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