Identification of SopE2, a Salmonella Secreted Protein Which Is Highly Homologous to SopE and Involved in Bacterial Invasion of Epithelial Cells

doi:10.1128/JB.182.8.2341-2344.2000

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Journal of Bacteriology, April 2000, p. 2341-2344, Vol. 182, No. 8
0021-9193/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.

Identification of SopE2, a Salmonella Secreted Protein Which Is Highly Homologous to SopE and Involved in Bacterial Invasion of Epithelial Cells

C. S. Bakshi,¹^,² V. P. Singh,¹^,² M. W. Wood,¹ P. W. Jones,¹ T. S. Wallis,¹ and E. E. Galyov¹^,^*

Institute for Animal Health, Compton, Berkshire RG20 7NN, United Kingdom,¹ and Indian Veterinary Research Institute, Izatnagar, Bareilly 243122, India²

Received 12 November 1999/Accepted 31 January 2000

Type III secreted Sop protein effectors are delivered into target eukaryotic cells and elicit cellular responses underlyingSalmonella pathogenicity. In this work, we have identified anothersecreted protein, SopE2, and showed that SopE2 is an importantinvasion-associated effector. SopE2 is encoded by the sopE2 genewhich is present and conserved in pathogenic strains of Salmonella.SopE2 is highly homologous to SopE, a protein encoded by a genewithin a temperate bacteriophage and present in only some pathogenicstrains.

^* Corresponding author. Mailing address: Institute for Animal Health, Compton, Berkshire RG20 7NN, United Kingdom. Phone: (44)1635 577291. Fax: (44) 1635 577243. E-mail: edouard.galyov{at}bbsrc.ac.uk.

Journal of Bacteriology, April 2000, p. 2341-2344, Vol. 182, No. 8
0021-9193/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.

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